abstract：:The fungal pathogen Candida albicans is frequently associated with catheter-based infections because of its ability to form resilient biofilms. Prior studies have shown that the transcription factor Bcr1 governs biofilm formation in an in vitro catheter model. However, the mechanistic role of the Bcr1 pathway and its ...

journal_title：PLoS pathogens

authors： Nobile CJ,Andes DR,Nett JE,Smith FJ,Yue F,Phan QT,Edwards JE,Filler SG,Mitchell AP

更新日期：2006-07-01 00:00:00

abstract：:Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive. While adult mice resist ZEBOV infection, the Mayinga strain of the virus has been adapted to cause lethal infecti...

journal_title：PLoS pathogens

authors： Ebihara H,Takada A,Kobasa D,Jones S,Neumann G,Theriault S,Bray M,Feldmann H,Kawaoka Y

更新日期：2006-07-01 00:00:00

abstract：:Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new effective vaccines and in the appropriate use of antimalarial drugs. By performing a full-genome s...

journal_title：PLoS pathogens

authors： Kidgell C,Volkman SK,Daily J,Borevitz JO,Plouffe D,Zhou Y,Johnson JR,Le Roch K,Sarr O,Ndir O,Mboup S,Batalov S,Wirth DF,Winzeler EA

更新日期：2006-06-01 00:00:00

abstract：:Control of virus infection is mediated in part by major histocompatibility complex (MHC) Class Ia presentation of viral peptides to conventional CD8 T cells. Although important, the absolute requirement for MHC Class Ia-dependent CD8 T cells for control of chronic virus infection has not been formally demonstrated. We...

journal_title：PLoS pathogens

authors： Braaten DC,McClellan JS,Messaoudi I,Tibbetts SA,McClellan KB,Nikolich-Zugich J,Virgin HW

更新日期：2006-05-01 00:00:00

abstract：:Legionella pneumophila translocates multiple bacterial effector proteins into host cells to direct formation of a replication vacuole for the bacterium. The emerging consensus is that formation of this compartment involves recruitment of membrane material that traffics between the endoplasmic reticulum (ER) and Golgi....

journal_title：PLoS pathogens

authors： Dorer MS,Kirton D,Bader JS,Isberg RR

更新日期：2006-04-01 00:00:00

abstract：:Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer. Given the role of this gene in viral defense, we sought to explore the possibility that a vira...

journal_title：PLoS pathogens

authors： Urisman A,Molinaro RJ,Fischer N,Plummer SJ,Casey G,Klein EA,Malathi K,Magi-Galluzzi C,Tubbs RR,Ganem D,Silverman RH,DeRisi JL

更新日期：2006-03-01 00:00:00

abstract：:Transmission of prions between species is limited by the "species barrier," which hampers a full characterization of human prion strains in the mouse model. We report that the efficiency of primary transmission of prions from Creutzfeldt-Jakob disease patients to a wild rodent species, the bank vole (Clethrionomys gla...

journal_title：PLoS pathogens

authors： Nonno R,Di Bari MA,Cardone F,Vaccari G,Fazzi P,Dell'Omo G,Cartoni C,Ingrosso L,Boyle A,Galeno R,Sbriccoli M,Lipp HP,Bruce M,Pocchiari M,Agrimi U

更新日期：2006-02-01 00:00:00

abstract：:Yersinia utilizes a sophisticated type III secretion system to enhance its chances of survival and to overcome the host immune system. SmpB (small protein B) and SsrA (small stable RNA A) are components of a unique bacterial translational control system that help maintain the bacterial translational machinery in a ful...

journal_title：PLoS pathogens

authors： Okan NA,Bliska JB,Karzai AW

更新日期：2006-01-01 00:00:00

abstract：:Plants and animals mediate early steps of the innate immune response through pathogen recognition receptors (PRRs). PRRs commonly associate with or contain members of a monophyletic group of kinases called the interleukin-1 receptor-associated kinase (IRAK) family that include Drosophila Pelle, human IRAKs, rice XA21 ...

journal_title：PLoS pathogens

authors： Dardick C,Ronald P

更新日期：2006-01-01 00:00:00

abstract：:Inhalation of fungal spores (conidia) occurs commonly and, in specific circumstances, can result in invasive disease. We investigated the murine inflammatory response to conidia of Aspergillus fumigatus, the most common invasive mold in immunocompromised hosts. In contrast to dormant spores, germinating conidia induce...

journal_title：PLoS pathogens

authors： Hohl TM,Van Epps HL,Rivera A,Morgan LA,Chen PL,Feldmesser M,Pamer EG

更新日期：2005-11-01 00:00:00

abstract：:Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both innate and adaptive immune responses. In the present study, we demonstrate that nucleotide-binding oligomerization domain 2 (NOD2)...

journal_title：PLoS pathogens

authors： Ferwerda G,Girardin SE,Kullberg BJ,Le Bourhis L,de Jong DJ,Langenberg DM,van Crevel R,Adema GJ,Ottenhoff TH,Van der Meer JW,Netea MG

更新日期：2005-11-01 00:00:00

abstract：:Since mucosal surfaces may be simultaneously colonized by multiple species, the success of an organism may be determined by its ability to compete with co-inhabitants of its niche. To explore the contribution of host factors to polymicrobial competition, a murine model was used to study the initiation of colonization ...

journal_title：PLoS pathogens

authors： Lysenko ES,Ratner AJ,Nelson AL,Weiser JN

更新日期：2005-09-01 00:00:00

abstract：:Cholera, the pandemic diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, continues to be a major public health challenge in the developing world. Cholera toxin, which is responsible for the voluminous stools of cholera, causes constitutive activation of adenylyl cyclase, resulting in the export o...

journal_title：PLoS pathogens

authors： Blow NS,Salomon RN,Garrity K,Reveillaud I,Kopin A,Jackson FR,Watnick PI

更新日期：2005-09-01 00:00:00